Cytokines

Name	Major Cellular Source	Selected Biologic Effects
IFN-α, β	Macrophages (IFNα) fibroblasts (IFNβ)	Antiviral
IFN-γ	CD4+ T cells, NK cells	Activates macrophages, TH1 differentiation
TNF-α	Macrophages, T cells	Cell activation, Fever, cachexia, antitumor
TNF-α, LT (lymphotoxin)	T cells	Activates PMNs
IL-1	Macrophages	Cell activation, Fever (Pro inflammatory)
IL-2	T cells	T cell growth and activation
IL-3	T cells	Hematopoiesis
IL-4	T cells, mast cells	B cell proliferation and switching to IgE, TH2 differentiation
IL-5	T cells	Differentiation of eosinophil, activates B cells
IL-7	Bone marrow stroma cells	T cell progenitor differentiation
IL-8	Macrophages, T cells	Chemotactic for neutrophils
IL-10	Macrophages, T cells	Inhibits activated macrophages and dendritic cells, Anti-inflammatory
IL-12	Macrophages	Differentiation of T cells, activation of NK cells
GM-CSF	T cells, macrophages, monocytes	Differentiation of myeloid progenitor cells
M-CSF	Macrophages, monocytes, fibroblasts	Differentiation of monocytes and macrophages
G-CSF	Fibroblasts, monocytes, macrophages	Stimulates neutrophil production in bone marrow