Genetic associations of some carcinomas

Gene	Disease
Trk A gene	Neuroblastoma (good prognosis)
RET proto oncogene	Medullary carcinoma thyroid
Rb gene (13q14)	Retinoblastoma
BRCA1	Ca breast (females)Ca ovary
APC gene	Familial adenomatous polyposis coli
Chromosome 3	Renal cell carcinoma
Trisomy 17, 7, 16, loss of y	Papillary renal carcinoma
11p13 WT-1	Wilm's tumor
Xp21	Duchenne muscular dystrophy
APP gene	Alzheimer's disease

Related articles

• Kidney Cancer Risk Factors (cancercenter.com)


• Renal Cell Carcinoma Cancer Types, Therapy & Diagnosis (cancercenter.com)

Chromosome & Disease

• Chromosome 1...Rh system / neuroblastoma


• Chromosome 2...cystinuria/hypobetalipoproteinemia


• Chromosome 3...RCC/ALKAPTONURIA


• Chromosome 4...huntingtons chorea/achondroplasia/parkinsons disease


• chromosome 5..FAP/colorectal ca/cri du chat syndrome


• chromosome 6...HLA system /MHA antigen/DM


• chromosome 7...Cystic fibrosis


• chromosome 8...osteoporosis


• chromosome 9...ABO blood group / friedreich's ataxia


• chromosome 10..Apert syndrome Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease, type 1 Charcot-Marie-Tooth disease, type 4 Cockayne syndrome congenital erythropoietic porphyria Cowden syndrome Crouzon syndrome Hirschprung disease multiple endocrine neoplasia type 2 Pfeiffer syndrome porphyri Usher syndrome Usher syndrome type I Wolman syndrome


• chromosome 11..sickle cell anaemia/beta thallasemia/wilms tumour/MEN -1/ataxia telengiectasia/human insulin gene/PTH gene


• chromosome 12...PKU/vWF/CA testes


• chromosome 13..retinoblastoma/osteosarcoma/wilsons ds


• chromosome 14..familial HOCM/ alpha 1 antitripsin deficiency


• chromosome 15..marfan's syndrome/albinism/pradder willi syndrome/angelman syndrome


• chromosome 16..alpha thallasemia/adult PKD


• chromosome 17..ca breast/medulloblastoma/neurofibromatosis-1/ovarian tumour/ P 53 gene


• chromosome 18..erythropoietic protoporphyria hereditary hemorrhagic telangiectasia Niemann-Pick disease/Type C porphyria Selective Mutism Edwards syndrome (Trisomy 18)


• chromosome 19..myotonia dystrophica/gene for insulin receptor


• chromosome 20..MODY type 1 DM/prions disease


• chromosome 21..homocystinuria/amyloidosis...folic acid transport..


• chromosome 22..meningioma/acoustic neuroma/NF -2/Di-George syndrome


• chromosome Xq..gene for androgen insensitivity syndrome/ fragile X syndrome/ Testicular feminisation/ X-SCID/ X linked agaamaglobulinemia/ Fabry ds/ Lesch- Nyhan/ Hemophilia B/ Hemophilia A/ Hunter syndrome/ G6PD deficiency


• chromosome Xp - Ocular albinism/ Chr Granulomatous Ds/ DMD/ Menkes syndrome